The side effects of Ozempic (semaglutide) range from common, mild gastrointestinal issues to rare, but potentially serious health conditions. Most common side effects are temporary and tend to lessen over time as the body adjusts to the medication.
Side effects occur in more than 1 in 10——related to the digestive system.
Nausea (most common)
Vomiting
Diarrhea
Stomach (abdominal) pain
Constipation
Loss of appetite
Heartburn/acid reflux
Burping, gas, or bloating
Fatigue or tiredness
Headache
Dizziness
Serious Side Effects (Rare)
Though uncommon, some side effects require immediate medical attention. The FDA has issued its most serious warning (boxed warning) about the risk of thyroid tumors.
Pancreatitis (inflammation of the pancreas), which may present as severe, persistent stomach pain
Thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). Symptoms can include a lump in the neck, hoarse voice, or trouble swallowing.
Severe allergic reactions (hives, swelling of the face/throat, difficulty breathing)
Hypoglycemia (very low blood sugar), especially if used with insulin or sulfonylureas
Gallbladder problems (gallstones or inflammation)
Acute kidney injury, often resulting from severe vomiting and diarrhea leading to dehydration
Changes in vision (worsening of diabetic retinopathy)
Intestinal blockage (ileus), where the intestines stop moving food and waste through the body
Increased heart rate (tachycardia)
While that list is intimidating, there is a drug advertised on TV for some condition which has a side effect of having your limbs fall off ...