Tramadol works great for me. It’s the only prescription pain medication that has ever taken away the pain. Most just make me loopy and make me not care about the pain. I took it sparingly after an auto accident. I have no side effects. My wife took some for an injury and it makes her sleep a long time and she doesn’t like how it makes her feel.
I’ve always wondered about medicine effects based on the various blood types. One wonders if that is even part of the testing for establishing trials.