Never mind, for us at least, the damage of long term exposure to radiation in something like say a trip to Mars?
Surviving, fault free and with with as much redundant equipment as you could afford to carry for a very long time seems very unlikely. Never say never and all that but the probabilities of success seem awfully low for something even as moderately adventurous as a trip to Mars at lest for our form of life anyway.
I’m not losing sleep about being wiped out by aliens who have ridden our radio transmissions to find out about us. It is possible but....
There are languages that evolved on Earth that we cannot decipher, to say nothing of the intricacies and metaphors that differ from culture to culture. These guys are going to have to decode the language and understand the message. Not as easy as we might think. Imagine they got the message and just thought it was static and ignored it 🤣