He basically abandoned his wife in the US. She pleaded with him to come home and he ignored her. She died when he was in France.
I believe he was in England at the time, agent for several of the colonies (1774). He had also pleaded with her to join him there. Like most of the other founders, other than Sam Adams, he was still against independence and thought it likely he would remain in London for the rest of his life as he saw himself most valuable to America in that sphere.