I have friend who has been on both. Yes, she’s lost weight. 70 lbs, over a roughly, but not quite, a 1 year period. However, both medications made her nauseous, so yeah, she’s stopped eating. You’ll lose weight if you pretty much have no appetite because everything you eat makes you sick to your stomach. That’s what she’s dealing with.
There was a period when we were all congratulating her. That was about 35 pounds ago. Now she looks withdrawn in her face. She LOOKS sick now. It’s getting hard to watch. I hope she stops. She needs to put a few pounds back on. She is a very sweet and kind person. I don’t care what she looks like. I want her to feel good about herself, but at what cost?
I'm a 5'-10" 73 year old male. My IBW based on four models is shown below. I'm currently over 190, so 30 pounds to shed to reach the highest IBW. But, I do know if I actually hit 165, I'd be skin and bones and look terrible, same as you describe your friend.