I’ve played a guitar my whole life and never noticed more than the the average of lefties playing. Never been a professional, but played with many, many people through the years. Not dissing anyone, I have 4 south paws in my immediate family.
I’m left-handed but play the guitar right-handed.
It was just easier to do the chords. I didn’t try reversing the strings.
Most left-handed people can use their right hand pretty well, due to the righthand nature of civilization. But in my experience most right-handed people are useless with their left hand.