baciamano
Posted on 02/28/2025 9:00:00 PM PST by ransomnote
Weighing the high cost of obesity reduction drugs
https://medicalxpress.com/news/2025-03-high-obesity-reduction-drugs.html
Excerpt:
Findings suggest that reducing the net prices of new antiobesity medications is necessary to improve accessibility.
Obesity affects more than 40% of U.S. adults and is associated with significant health and economic burdens. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as semaglutide and tirzepatide have demonstrated effectiveness in promoting weight loss and reducing cardiometabolic risks. Increased demand has resulted in supply shortages, while high costs have prompted restrictive insurance coverage policies.
Previous studies evaluating the economic value of these medications have produced conflicting results. Some analyses identified semaglutide as cost-effective compared to no treatment, whereas others concluded that tirzepatide and semaglutide were not cost-effective relative to lifestyle modification alone.
Inconsistencies in prior findings stemmed in part from reliance on clinical trial populations and pricing estimates rather than real-world data.
.....Data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) were used, comprising 4,823 individuals aged 20 to 79 years, representing approximately 126 million eligible U.S. adults.
Participants met clinical trial criteria for antiobesity medications based on body mass index (BMI) and the presence of at least one weight-related comorbidity. Researchers applied individual-level simulations with probabilistic sensitivity analyses and subgroup assessments to account for BMI classifications, presence of comorbidities, and treatment discontinuation rates.
Each intervention included either lifestyle modification alone or lifestyle modification combined with one of four medications: naltrexone-bupropion, phentermine-topiramate, semaglutide, or tirzepatide. Lifestyle modification consisted of dietary changes and physical activity.
.....Tirzepatide prevented 45,609 cases of obesity per 100,000 individuals, the highest reduction among all interventions. Diabetes cases decreased by 20,854 per 100,000 individuals, while cardiovascular disease cases declined by 10,655 per 100,000 individuals.
Semaglutide showed a lower, yet significant, impact, preventing 32,087 obesity cases, 19,211 diabetes cases, and 8,263 cardiovascular disease cases per 100,000 individuals. Life-years and QALYs gained were highest for tirzepatide (0.50 life-years, 0.35 QALYs) and semaglutide (0.35 life-years, 0.25 QALYs).
Cost-effectiveness evaluations determined that naltrexone-bupropion was cost-saving, with an 89.1% probability of being cost-effective at the $100,000/QALY threshold. Phentermine-topiramate demonstrated a 23.5% probability of cost-effectiveness at the same benchmark.
Tirzepatide and semaglutide were deemed not cost-effective at current pricing, with incremental cost-effectiveness ratios (ICERs) of $197,023/QALY and $467,676/QALY, respectively. To achieve cost-effectiveness under the $100,000/QALY standard, price reductions of 30.5% for tirzepatide and 81.9% for semaglutide would be required.
Subgroup analyses indicated greater QALY gains among individuals with pre-existing comorbidities, suggesting that antiobesity medications may provide the most value for those at higher health risk. Sensitivity analyses reinforced the findings, with probabilistic simulations showing that tirzepatide and semaglutide remained economically inefficient across all cost-effectiveness thresholds examined.
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Pushing the diabetes drugs as a solution to obesity using vague terminology and small data defined as real world. Doesn’t even mention the serious side effects of each drug which would effect quality of life measurement they try to use. FDA has approved the drugs for obesity as well as diabetes. Using 4,800 people over 4 years to extrapolate out for 128 million people games drug companies, medical research and the FDA play. Is a Phen-fen disaster lurking in the future?
Feel good story of the day:
Greenpeace Loses Dakota Access Pipeline Trial, Faces Bankruptcy and Extinction
https://x.com/RyanMaue/status/1902479326626373709
The end of a leftist green scam group is on the horizon one hopes after this case.
Lofoten Islands, Norway
These Metro Stations SHOCKED the World! Moscow, Russia
Window to Moscow
https://www.youtube.com/watch?v=dLBllo1fbl4
Puts US subways to shame. In fairness almost all US subways are run by demofascist and/gov. swamp critters.
“A public bus in Dublin. Conor McGregor was right. Does this look like Ireland to you? https://t.co/Yc8C9S91m6” / X
https://x.com/Mick_O_Keeffe/status/1902331654380650797
Not the Canada I grew up in for sure.
Watch: A fearless Canadian woman interrupted a public Muslim prayer where pro-Palestinian Muslim supremacists blocked an entire area—not because they lacked mosques (there are dozens nearby), but to assert dominance in public space.
Twitter ^ |
https://freerepublic.com/focus/f-chat/4305465/posts
Look at the background around Roberts head.
There’s a difference between it and the areas around the other guys’ heads.
Looks like Roberts was photoshopped in.
Who posted that picture originally?
Is it a ploy to divert attention from what Roberts did to adopt his kids, or some other dirt that exists on him?
Or is it misinformation spread to get our side to bite, then they debunk it and our side is discredited?
I do not know... I remember the photo from long ago but “Roberts” wasn’t in it; when I posted this one from someone else’s link, I figure the other photo might be cropped. Sorry I posted it.
Let parents bequeath to their children not riches,
but the spirit of reverence.
Plato
Goodnight LJ!
Under President Trump’s leadership, we will not sit idly by as conservative new media and their families are being targeted by false swatting. @DHSgov has the ability to trace phone numbers and track location information. We will use it to hunt these cowards down.
This is an attack on our law enforcement and innocent families and we will prosecute it as such.— Secretary Kristi Noem (@Sec_Noem) March 19, 2025
Another thread reported this was not JR, but Chelsea Clinton’s husband.
For while we were still weak, at the right time Christ died for the ungodly. — Romans 5:6 (ESV)
And he answered them, “Whoever has two tunics is to share with him who has none, and whoever has food is to do likewise.” — Luke 3:11 (ESV)
ransomnote: The following article is on a website for a company in Virginia owned by Gannett Publications which does not permit the posting of excerpts on Free Republic (Allows link and Title only).Fort Gregg-Adams museum removes display honoring transgender soldiers amid Trump DEI order
ransomnote: The display is located at the U.S. Army Women’s Museum at Fort Gregg-Adams. A separate exhibit at the museum on the army’s Sexual Harassment/Assault Response and Prevention program will also be removed. The museum's Facebook page will be reviewed to align with Trump's objectives.
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