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I'm really not sure. I know there is a YDNA project trying to link families with oral histories of descent from the Lost Colony, but not sure the current status of that. There is also the Chowan Stone and the Dare Stones to add another wrinkle to the story. I think it's highly likely that they fled up the river and were captured and enslaved by Natives. https://en.wikipedia.org/wiki/Dare_Stones

While my family doesn't have any Lost Colony history, I do follow the research. The river passages through North Carolina are of utmost research interest because they were the highways of the time and most migratory paths occurred along them. The Lost Colony could have taken any of them and ended up anywhere.

One of my college roommates was from Dare County and her family had been there forever. I swear she looked like the Disney Pocahontas, but she had no knowledge of her family history.