Can your diet help reduce brain iron and cognitive decline?

I have had two separate doctors confirm my experience is due to the anti-oxidants. Both said almost exactly the same thing:

“Oh yeah, that works. We’re all on them. But we don’t make any money prescribing them.”

Separately. Only the Quercetin comes with the C.

Plus melatonin separately for sleep, but helpful as noted in the article.

You may recognize Quercetin, EGCG and Melatonin as early compounds found helpful I warding off Covid. Here’s what ChatGPT has to say:

Have Quercetin, EGCG and Melatonin been shown to help avoid or ameliorate Covid 19 infections?

ChatGPT said:

ChatGPT

There has been interest in whether certain supplements like Quercetin, EGCG (Epigallocatechin gallate), and Melatonin can help avoid or ameliorate COVID-19 infections. Below is a summary of available research:

1. Quercetin

Quercetin is a flavonoid with anti-inflammatory, antioxidant, and immune-boosting properties. Some studies have suggested that Quercetin might have potential benefits in managing COVID-19 due to its ability to inhibit viral replication and modulate the immune response. For example:

In vitro studies have shown that Quercetin could inhibit the replication of SARS-CoV-2, the virus responsible for COVID-19, by interfering with viral entry and replication mechanisms.Some clinical trials have explored Quercetin as a potential adjunctive treatment for COVID-19, but the evidence is still preliminary. The studies are small and do not yet provide robust proof that it is effective in preventing or treating COVID-19.

However, while Quercetin has promising properties, more well-controlled human clinical trials are needed to establish its role in COVID-19 management.

2. EGCG (Epigallocatechin gallate)

EGCG, a major polyphenol in green tea, is known for its antioxidant, anti-inflammatory, and antiviral properties. Some research suggests EGCG may help prevent viral infections by inhibiting viral attachment and entry into host cells.

In vitro studies have shown that EGCG can inhibit the replication of several viruses, including coronaviruses.Some research has suggested that EGCG might help in managing COVID-19, especially because it may interact with the spike protein of the virus, potentially reducing its ability to infect cells. However, while EGCG shows antiviral promise, its effectiveness specifically against COVID-19 has not been conclusively demonstrated in large-scale human studies.

Similar to Quercetin, EGCG’s role in COVID-19 remains speculative without more conclusive clinical data.

3. Melatonin

Melatonin, a hormone primarily involved in regulating the sleep-wake cycle, has been proposed as a potential adjunct for COVID-19 treatment. It has anti-inflammatory and antioxidant effects, and may help modulate the immune system, which could be beneficial in controlling the inflammatory response associated with COVID-19.

Research suggests that melatonin might help reduce the severity of symptoms, particularly in older adults, by mitigating cytokine storms (overactive immune responses) and improving sleep quality, which could support immune function.Some studies have indicated that melatonin could help reduce the risk of severe COVID-19 outcomes, particularly in high-risk populations like the elderly or those with comorbidities. However, these studies are preliminary, and more high-quality research is required to firmly establish its benefits.Summary

While there is some evidence to suggest that Quercetin, EGCG, and Melatonin might have beneficial effects in the context of COVID-19, particularly in terms of immune support and viral inhibition, none of these supplements have been conclusively proven to prevent or treat COVID-19 infections. More research, especially large-scale clinical trials, is needed to determine their efficacy and safety for COVID-19 specifically.

It’s important to consult a healthcare professional before using these or any supplements as a treatment or preventive measure for COVID-19.

window.__oai_logHTML?window.__oai_logHTML():window.__oai_SSR_HTML=window.__oai_SSR_HTML||Date.now();requestAnimationFrame((function(){window.__oai_logTTI?window.__oai_logTTI():window.__oai_SSR_TTI=window.__oai_SSR_TTI||Date.now()}))

ChatGPT can make mistakes. Check important info.

We take all of those, minus the berberine.

Good health to you!

If you’re on that same program, you’re obviously up on your stuff.

What else do you take that I should consider?

Oh my, I take a whole lot more, but what do you have problems with? Prostate? Varicose veins / hemorrhoids? Eye issues?

None of the above. But the anti-oxidant regimen is clearly excellent for general health. Anything else you think works along those lines is what I’m after.

For example, I’m on Vitamin D, one of the only proven anti-cancer compounds known. My blood serum level is in the 60s, which is optimal.

I take a multivitamin as insurance.

Blueberries and dark chocolate for dessert.

Protein over carbs.

Exercise like a demon.

What else ya got?

For documentation and posterity:

What cancers has vitamin D been shown to reduce the probability of, or reduce the mortality from?

ChatGPT said:

ChatGPT

Vitamin D has been studied for its potential role in cancer prevention and mortality reduction, and while the evidence is still evolving, there are several cancers where it appears to play a beneficial role:

Colorectal Cancer: Numerous studies suggest that higher vitamin D levels are associated with a reduced risk of colorectal cancer. Some evidence also points to vitamin D’s ability to lower mortality in those with the disease.

Breast Cancer: Observational studies have indicated that higher levels of vitamin D are linked to a reduced risk of breast cancer, particularly postmenopausal breast cancer. There is also some evidence suggesting that adequate vitamin D may improve survival outcomes for those diagnosed with breast cancer.

Prostate Cancer: Research has shown a potential protective effect of vitamin D against prostate cancer, particularly in reducing the risk of aggressive forms of the disease. However, the evidence is mixed regarding vitamin D’s impact on prostate cancer mortality.

Lung Cancer: While the evidence is less robust than for other cancers, some studies suggest that adequate vitamin D levels may be associated with a reduced risk of lung cancer and potentially better outcomes in those with the disease.

Ovarian Cancer: Some studies suggest that higher vitamin D levels may reduce the risk of ovarian cancer, although the findings are not as conclusive as for other cancers.

Esophageal Cancer: There is emerging evidence suggesting that adequate vitamin D levels may be linked to a reduced risk of esophageal cancer, particularly in people with certain genetic predispositions.

Endometrial Cancer: Some research points to a protective role of vitamin D in reducing the risk of endometrial cancer.

Non-Hodgkin Lymphoma: Some studies have found that higher levels of vitamin D may be associated with a reduced risk of developing non-Hodgkin lymphoma.

Mechanisms:

Vitamin D may help regulate cell growth, apoptosis (programmed cell death), and immune function, which are all important for preventing cancer. It also may modulate the activity of certain genes involved in cancer development and progression.

Caution:

While the evidence for vitamin D’s potential role in cancer prevention is promising, it’s important to note that more rigorous clinical trials are needed to confirm these benefits. Moreover, vitamin D supplementation should be approached carefully, as excessive intake can lead to toxicity, particularly with high doses.

In summary, vitamin D shows promise in reducing the risk of certain cancers like colorectal, breast, and prostate cancer, and may also improve survival outcomes, but more research is required to establish definitive guidelines.

window.__oai_logHTML?window.__oai_logHTML():window.__oai_SSR_HTML=window.__oai_SSR_HTML||Date.now();requestAnimationFrame((function(){window.__oai_logTTI?window.__oai_logTTI():window.__oai_SSR_TTI=window.__oai_SSR_TTI||Date.now()}))

ChatGPT can make mistakes. Check important info.

Here’s your Berberine primer: (Apologies for lack of paragraphs...)

What are some scientifically proved benefits of berberine?

ChatGPT said:

ChatGPT

Berberine, a bioactive compound found in several plants, has been studied for its potential health benefits. Several scientifically supported effects of berberine have been observed, particularly in relation to metabolic health, cardiovascular function, and microbial balance. Here are some key scientifically proven benefits:

1. Improves Insulin Sensitivity and Blood Sugar ControlType 2 Diabetes: Berberine has been shown to help lower blood sugar levels by improving insulin sensitivity. A number of studies have demonstrated that berberine can be as effective as some pharmaceutical drugs (e.g., metformin) in reducing blood glucose levels and HbA1c.Mechanism: It works through multiple mechanisms, including activating AMP-activated protein kinase (AMPK), which plays a role in regulating glucose and lipid metabolism, and improving insulin signaling.2. Supports Weight LossBerberine has been shown to aid in weight loss, particularly in individuals with metabolic syndrome or obesity. Clinical studies suggest that it can reduce fat accumulation and improve fat metabolism.Mechanism: It activates AMPK, which boosts fat burning and inhibits fat storage. It may also regulate gut microbiota, which is involved in weight regulation.3. Improves Lipid Profile and Cardiovascular HealthBerberine has beneficial effects on cholesterol levels. It can reduce total cholesterol, LDL (bad) cholesterol, and triglycerides, while increasing HDL (good) cholesterol.Some studies also suggest berberine may help lower blood pressure, reducing the risk of heart disease.4. Has Antimicrobial and Anti-inflammatory EffectsBerberine has been shown to exhibit antimicrobial properties against a range of pathogens, including bacteria, fungi, and parasites. It may help in treating infections such as diarrhea caused by E. coli and Giardia.It also has anti-inflammatory effects, which may help reduce chronic inflammation associated with conditions like arthritis, cardiovascular disease, and metabolic syndrome.5. Improves Gut HealthBerberine may help balance the gut microbiota, supporting beneficial bacteria and reducing harmful microorganisms. This balance is crucial for digestive health and may have broader implications for metabolic health.Studies suggest that berberine can improve gut permeability and may help manage conditions like irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD).6. Potential Cancer-Fighting PropertiesSome early studies suggest that berberine may have anticancer effects by inhibiting cancer cell growth, inducing apoptosis (programmed cell death), and reducing metastasis (spread of cancer).Mechanism: It may interfere with cell signaling pathways involved in cancer growth, though further research is needed to fully understand its potential as an adjunct to cancer treatment.7. May Improve Liver FunctionBerberine has been shown to help reduce liver fat and improve liver function, particularly in conditions like non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).It can lower liver enzyme levels and improve the liver’s ability to metabolize fats and sugars.8. Potential Benefits in Polycystic Ovary Syndrome (PCOS)Berberine has been found to improve insulin sensitivity and menstrual regularity in women with PCOS, making it a potential alternative to drugs like metformin.It may help reduce androgen levels, which can alleviate symptoms like excess hair growth (hirsutism) and acne.9. Neuroprotective EffectsPreliminary studies indicate that berberine may have neuroprotective effects, potentially offering benefits in neurodegenerative diseases like Alzheimer’s and Parkinson’s. It may help by reducing oxidative stress, inflammation, and improving mitochondrial function.10. Anti-Aging EffectsThrough its activation of AMPK and its effects on cellular energy production and metabolism, berberine may have potential anti-aging benefits. It may improve mitochondrial function and protect against age-related cellular damage.Summary of Key Mechanisms:AMPK Activation: This key enzyme plays a crucial role in regulating metabolism and energy balance. Berberine’s activation of AMPK explains many of its benefits, such as improved glucose metabolism, fat loss, and lipid regulation.Gut Microbiota Modulation: Berberine can help balance gut bacteria, which is increasingly understood to influence everything from metabolism to immune function.Antioxidant and Anti-inflammatory Properties: These effects help reduce chronic inflammation and oxidative stress, which are implicated in various diseases, including heart disease, cancer, and neurodegenerative conditions.Conclusion:

Berberine is a promising natural supplement with multiple scientifically backed health benefits, particularly for managing blood sugar, improving metabolic health, supporting cardiovascular function, and enhancing gut health. However, it’s important to consult with a healthcare provider before using berberine, especially for individuals on medication for diabetes or cardiovascular disease, as it can interact with other drugs.

window.__oai_logHTML?window.__oai_logHTML():window.__oai_SSR_HTML=window.__oai_SSR_HTML||Date.now();requestAnimationFrame((function(){window.__oai_logTTI?window.__oai_logTTI():window.__oai_SSR_TTI=window.__oai_SSR_TTI||Date.now()}))

ChatGPT can make mistakes. Check important info.

I make sure I get in over 50 separate items a day. There are reasons for each of them, and I have customized them for my wife and others, but it would take a long time to detail them. I will say I have posted threads on at least 3/4 of them, here, over the years.

Urolithin A, small amounts of nicotinamide riboside, soluble fiber 40+ grams a day, taurine, manganese, reduced copper/increased zinc, probiotics, GLA, Endocalyx Pro, carnosine, bilberry, pycnogenol, milk thistle, citicholine, ergothioneine (or daily mushrooms), citrus bergamot, ubiquinol, tocotrienols, lycopene, boron, and more make up what I take each day. Collagen peptides and glycine I also take.

There’s some more, with vitamins, minerals, and antioxidants, but these are what come to mind, right now.

Eat an apple a day and keep the doctor away.