“In aged mice with critical-size defects, alternating-day intermittent fasting restored osteogenic compartment health, improving CD90+ cell function as well as bone remodelling and significantly enhanced bone repair to levels comparable to younger animals. This effect was recapitulated by even shorter- term supplementation of the gut bacteria Akkermansia muciniphila or nicotinamide mononucleotide (NMN – an NAD+ precursor) in aged mice, highlighting the multifaceted mechanisms of action of intermittent fasting. We further identify mitochondrial dysfunction as a key component in age-related decline in osteoprogenitor function and show that both cyclical nutrient deprivation or NMN rejuvenate mitochondrial health and enhance osteogenesis in vitro.”
Thanks CM, I figured you’d read it! So, for humans, it may (maybe ‘probably’) means several days of fasting to get the same result. Sounds like a good thing to study!