They lost when they declared war on the US. Hitler was blind to the fact that Japan wasn’t going to help them against the Russians.
Yep....I've been watching a good series on WW2 and this point is made.
Once the US and our population and industrial capability were added to the allies, it was just a matter of time before the Axis powers lost.
It also illustrates the lack of coordination between Germany and Japan on their war plans.