Best hope for cloudless days, and time to let the beam dwell long enough to cook the damn things.
A reliable 100KW laser is considered the threshold for a useful defensive device. Assuming that targeting and power supply needs are met, lasers can be tuned to penetrate clouds. And if this device is reliable and works under combat conditions, the result will be rapid development and deployment of similar defensive lasers.
Lasers can penetrate water vapor. And, if “barrel” rotates like gatling gun, no problem. Don’t forget, expendable air vehicles cannot be adequately armored and still move fast enough to do the job.
This is the tech that will forever end air superiority.