[ConservativeMind]

SGLT2is includes Jardiance. GLP1-RAs includes Ozempic.

Major quotes:

“SGLT2is reduced the risk of major adverse cardiovascular events (myocardial infarction, stroke, or cardiovascular death) by 11% and hospitalization for heart failure or cardiovascular death by 23% versus placebo, even when added to GLP1-RAs.”

“SGLT2is also reduced the risk of chronic kidney disease progression by 33% when added to GLP1-RAs and slowed the annual loss of kidney function by almost 60% when added to GLP-1RAs. No new safety concerns were identified when SGLT2is and GLP-1RAs were used in combination.”

Taking both types of drugs provides big benefits.

I will suggest this tells me just how important reducing all calories and greatly adjusting how carbs are used, really is. The drugs appear to do amazing things together, but diet and exercise might come close to parts of these results, too.

[ConservativeMind]

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[JParris]

But, but, but,....

Off label use of a drug?? We have been advised ad nauseum that is not allowed.......