Vance would be great, a lot better than presumed favorite Nothingburger Burgum (Mike Pence 2.0 without the sanctimonious bible-thumping).
I called long ago for it to be Glenn Youngkin, but a fighter like Vance would be welcome on the ticket.
Note however that Vance would be replaced in the Senate by somebody much less conservative. Not a Democrat, but a squishy DeWine-type Republican. The worst possible (and therefore most likely?) option along those lines would be congressman Mike Turner.
I don’t think you should worry too much about the senate seat
If Vance is the man for the job he should get it regardless.
It’s a promotion on to the national stage
In the Senate he does nothing but show up and vote. 90% with leadership anyway and so will his replacement