I’m a doc.
Was in my Residency when this happened in 89.
Learned then that Remdesivir killed liver and kidneys when we were treating Ebola and we stopped using it.
Couldn’t believe we started using again. Malpractice on steroids!!!
I cannot find any information on Remdesivir back before 2009. Back in the late eighties all the talk was about anti-virals for AIDS. In 1984, when the National Cancer Institute started using AZT with AIDS, there were almost no effective anti-virals for any disease. By the mid-nineties the scientists at NCI had developed a combination therapy which drastically reduced AIDS related deaths.1
Here I quote from an article on the history which says,
"Remdesivir (GS-5734) was developed by Gilead Sciences and emerged from a collaboration between Gilead, the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). They sought to identify therapeutic agents for treating RNA-based viruses that maintained global pandemic potential, such as those that indeed emerged following the initiation of the program, including EBOV and the Coronaviridae family viruses exemplified by Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS)." 2
It was tried against SARS and MERS in 2012 I think, and again in the Ebola outbreak of 2014 in Congo, where it was found inferior and where it showed the kidney and liver difficulties you mentioned. A study out of Leiden University Med. Cntr. on liver and kidney function claims that it was not severe.3
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1)"The First AIDS Drugs"
3)Liver and kidney function in patients with Covid-19 treated with remdesivir