I saw Huey Lewis and the News on my college campus, had to be 1982 or 1983, playing on an outdoor stage at a campus music and art festival, and there wasn't more than two dozen people listening. Huey said that they were working on a new song, and played "I Want a New Drug."
Being the straight-laced guy I was back then, I thought to myself "bah, I don't like songs about drugs" and left.
Either later that year or the next he was on SNL and the rest was history. (And I came to really like his music, including New Drug...)
On that same theme; Brian Ferry and Roxy Music had a big dance tune hit with the song “Love Is The Drug”.
A European disco crooner.