“When testing fenoprofen in an established rat model of endometriosis, fenoprofen successfully alleviated endometriosis-associated vaginal hyperalgesia, a surrogate marker for endometriosis-related pain. These findings validate fenoprofen as a therapeutic that could be utilized more frequently for endometriosis.”
“We leverage a publicly available gene expression dataset of 105 endometriosis and healthy control samples which are further stratified into several comparisons: Control vs. all phases and all stages, Control vs. all stages stratified by menstrual phase, Control vs. Stage I-II or Stage III-IV for all menstrual phases. The resulting signatures are then queried against a collection of human cell lines treated with a number of therapeutic compounds for drugs that significantly reverse the disease associated expression. A candidate of interest is further validated in an animal model.”
In sum, they looked at over 3,100 genes and 299 drugs known to address those genes.
Again, from the paper:
“As fenoprofen had the highest reversal score of our drug candidates and belongs to a gold standard treatment category of drugs for endometriosis, our validation efforts herein were focused on this medication.”
Models may be of use in selecting drugs for actual trials. They are not the same as actual trials.
You’re not allowed to repurpose drugs. Remember ivermectin?
I’m not sure how they measure pain in animals.
Maybe if they jump out of their restraints and bite the lab tech in the thigh?
Think about it.