No, because both are from CA
I don’t think that matters. Looks like the new president can fill the VP position with who they like as long as congress approves it.
I think the point I am making is that would put Newsom into the position of incumbency as VP to run for President in 2024. He would already be halfway through the door to the Oval Office.
https://constitution.congress.gov/constitution/amendment-25/