I suspect that the mechanism which enables the genetic variability cited with these migrations involves the susceptibility to prion replication, and that is responsible for the increased incidence of MS and Alzheimer’s disease. UC San Francisco researchers have associated Alzheimer’s disease with attack by two successive prions. I suspect that, if researched, MS would go a similar route, especially since MS is autoimmune. The human immune system attacks things which it recognizes as foreign.
https://www.ucsf.edu/news/2019/05/414326/alzheimers-disease-double-prion-disorder-study-shows
https://www.ucsf.edu/news/2001/08/97139/ucsf-study-finds-two-old-drugs-may-help-fight-prion-diseases
Plain English explanations of disease are often very hard to find.
I am hopeful that medical AI and re-purposed drugs will speed up the decades of research and testing that are now required to move medical treatments forward, at a glacial pace.