[ConservativeMind]

Only 13% had an overactive immune system issue when prophylactically treated with tocilizumab, with their immunotherapy, versus 72% without it (normal treatment).

They found no issues with immunotherapy efficacy, when adding the tocilizumab.

[ConservativeMind]

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[ransomnote]

https://www.mayoclinic.org/drugs-supplements/tocilizumab-intravenous-route-subcutaneous-route/side-effects/drg-20073821?p=1

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

 

More common

1. Black, tarry stools
2. bloody or cloudy urine
3. blurred vision
4. body aches or pain
5. chest pain or tightness
6. chills
7. cough with or without mucus
8. diarrhea
9. difficult, burning, or painful urination
10. difficulty breathing
11. difficulty swallowing
12. dizziness
13. ear congestion
14. fast heartbeat
15. feeling of warmth
16. fever
17. frequent urge to urinate
18. headache
19. hives, itching, skin rash
20. loss of appetite
21. loss of consciousness
22. loss of voice
23. lower back or side pain
24. nausea
25. nervousness
26. pain or tenderness around the eyes and cheekbones
27. painful blisters on the trunk of the body
28. pale skin
29. pounding in the ears
30. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
31. redness of the face, neck, arms, and occasionally, upper chest
32. slow or fast heartbeat
33. sneezing
34. sore throat
35. stomach pain
36. stuffy or runny nose
37. sudden sweating
38. ulcers, sores, or white spots in the mouth
39. unusual bleeding or bruising
40. unusual tiredness or weakness

Less common

1. Accumulation of pus
2. anxiety
3. bladder pain
4. burning feeling in the chest or stomach
5. confusion
6. dark urine
7. decrease in height
8. decreased urine
9. difficulty moving
10. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
11. dry mouth
12. fast, irregular, pounding, or racing heartbeat or pulse
13. feeling hot
14. general feeling of discomfort or illness
15. heartburn
16. increased thirst
17. indigestion
18. itching, pain, redness, swelling, tenderness, or warmth on the skin at the injection site
19. joint pain
20. light-colored stools
21. loss of appetite
22. mood changes
23. muscle ache, pain, cramp, or stiffness
24. numbness or tingling in the hands, feet, or lips
25. pain in the back, ribs, arms, legs, groin, or genitals
26. severe stomach pain
27. sharp back pain just below the ribs
28. shivering
29. stomach upset
30. sweating
31. swollen joints
32. swollen, painful, or tender lymph glands in the face, neck, armpit, or groin
33. swollen, red, or tender area of infection
34. tenderness in the stomach area
35. trouble with sleeping
36. unexplained runny nose or sneezing
37. vomiting
38. yellow eyes and skin

Rare

1. Belching
2. changes in skin color
3. coughing or spitting up blood
4. fainting
5. gaseous stomach pain
6. lightheadedness
7. neck pain
8. night sweats
9. noisy breathing
10. rapid, shallow breathing
11. recurrent fever
12. red, tender, or oozing skin at the wounded area
13. sudden high fever or low-grade fever for months
14. swelling of the foot or leg
15. weight loss

Incidence not known

1. Blistering, peeling, loosening of the skin
2. bloating
3. dilated neck veins
4. pains in the stomach, side, or abdomen, possibly radiating to the back
5. red skin lesions, often with a purple center
6. red, irritated eyes
7. severe stomach pain, cramping, or burning
8. swelling of the face, fingers, feet, or lower legs
9. vomiting of material that looks like coffee grounds, severe and continuous
10. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Burning, dry, or itching eyes
2. constipation
3. discharge, excessive tearing
4. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
5. skin rash, encrusted, scaly and oozing
6. swelling or inflammation of the mouth

Less common

1. Abnormal or decreased touch sensation
2. bleeding or redness and swelling of the gums
3. blemishes on the skin
4. bloody eye
5. chapped, red, or swollen lips
6. earache
7. feeling of constant movement of self or surroundings
8. irritation in the mouth
9. loose teeth
10. persistent breath odor or bad taste in your mouth
11. pimples
12. redness or swelling in the ear
13. scaling, redness, burning, pain, or other signs of inflammation on the lips
14. sensation of spinning
15. sore mouth or tongue
16. white patches in the mouth or on the tongue

Rare

1. Bleeding after passing stool
2. blindness
3. bloody nose
4. burning, numbness, tingling, or painful sensations
5. change in hearing
6. continuing ringing or buzzing or other unexplained noise in the ears
7. coughing or spitting up blood
8. decreased vision or other changes in vision
9. dry mouth
10. ear drainage
11. flushed, dry skin
12. fruit-like breath odor
13. hearing loss
14. increased hunger, thirst, urination
15. itching ears
16. uncomfortable swelling around the anus
17. unexplained weight loss
18. unsteadiness or awkwardness
19. weakness in the arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

[FlipWilson]

Friend of mine was being treated with Keytruda. Worked on the cancer but attacked her liver. This article is helpful.

[sauropod]

bkmk