The main consequences of the Plague in Europe was the disintegration of the feudal system, interest in the scientific method, the Renaissance, the Reformation, the rise of banking and capitalism, and the Age of Sail with European expansion across the Earth and worldwide trade.
The Plague hit a number of times, going back thousands of years, so it's likely to have had impacts on prehistoric societies as well, we just don't know what those impacts were.
My ancestors survived the plague.
Multiple times.
Survived the Spanish Flu.
Modern lifestyles, modern medicine...not so much.