” any mRNA that is in the vaccine (and all other vaccine components) are gone within 48 hours after vaccination.”
Uhh No and its not mRNA its Modified mRNA and it lasts at least for +180 days.
The vaccine mRNA enclosed in the LNP is NOT a normal RNA that would otherwise be destroyed in minutes. It has a nucleic acid substitutions that make it more difficult for the body or cell to degrade. This altered mRNA exists for weeks.
Highlights
• Vaccination confers broader IgG binding of variant RBDs than SARS-CoV-2 infection
• Imprinting from initial antigen exposures alters IgG responses to viral variants
• Histology of mRNA vaccinee lymph nodes shows abundant GCs
The Money shot: see below.
• Vaccine spike antigen and mRNA persist for weeks in lymph node GCs
https://rwmalonemd.substack.com/p/when-is-mrna-not-really-mrna?s=r
“the “mRNA” from the Pfizer/BioNTech and Moderna vaccines which incorporates the synthetic nucleotide pseudouridine can persist in lymph nodes for at least 60 days after injection. “
First of all, links to blogs are not scientific references. So I will skip the blog and move on to the Cell article.
The Cell article (which I have actually read several times since it was published) only mentions that they found vaccine mRNA through RT-PCR analysis of GCs. This is very much a stand-alone finding; it is not placed into any context of, for example, viral mRNA longevity in the GCs. GC is short for “Geminal Center.” This is the location of the lymph node where B-cells differentiate and mature. The GCs typically hold on to pathogen originated biological molecules for a prolonged period of time in order to mature the B-cells (which in turn produce the antibodies). Furthermore, this mRNA may still be encapsulated within the nanoliposomes, as I discuss further down. What this does NOT provide evidence for is the antivax fearmongering about mRNA altering DNA. Within the GCs, as elsewhere in the body, mRNA does not enter the cell nucleus or mitochondria (the two places where DNA lives) and does not interact with DNA.
I will note here that the study published in Cell found that GCs in lymph nodes of people with severe Covid were damaged. This helps to explain why people with Covid sometimes fail to produce an immune response, or their immune response is weak. It also helps to explain why Covid is so serious and life-threatening.
Here is a study that more directly examined the persistence of vaccine mRNA: “Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313234/
The authors of this study found vaccine mRNA in the serum fraction of blood as many as 15 days after vaccination. However, they pointed out that this is probably still encapsulated within the LNP, since naked mRNA would be degraded almost immediately upon contact with serum. However, they found almost no mRNA in any of the blood cells after day six. What this suggests to me is that the adhesion of the LNPs to cell membranes with subsequent fusing and release of contents into the cytoplasm is inefficient, but once it occurs, the vaccine components rapidly undergo enzymatic degradation.
The authors of this study hypothesized that the persistence of mRNA-containing LNPs in serum helps to strengthen the immune response. Serum flows in the lymphatic fluid as well as the blood; the adaptive immunity response (i.e. B- and T-cell maturation and antibody production) takes place in lymph nodes.
And this does not invalidate my statement that mRNAs typically have a half-life of hours. This is just as true of the vaccine mRNA. The only reason it lasts longer in certain cases is because the LNP protects it from RNAse mediated degradation. If that vaccine mRNA were injected directly as a solution without the LNPs to protect it, I doubt it would last long enough to reach the lymph nodes.
My last comment is on Dr. Robert Malone, or, as I knew him, Bob. I do not know why he is so set on spreading misinformation to conservatives; he did not seem like a kook when I worked in his lab as a new grad student or years later when I saw him giving a seminar. So, why is he targeting conservatives? Perhaps he started doing this to undermine Trump. I suspect that a lot of leftists are specifically marketing antivax propaganda to conservatives initially to undermine Trump and now to discredit conservatives (and get us to die in higher numbers from Covid). Bob struck me as fairly liberal and his wife Jill even more so. He knows as well as I do that laypeople do not typically have the education or experience to read the scientific literature. But he uses that knowledge to bamboozle people and scare them using scientific terminology that sounds daunting, while I use that knowledge to try to educate people.
Do you never wonder why all of the leftist antivax fearmongers never hit the leftist talk show circuits? Maybe it’s because they want only conservatives to believe that tripe.