Ozempic® is a GLP‑1 analog
https://www.sciencedirect.com/topics/medicine-and-dentistry/glucagon-like-peptide-1
Glucagon Like Peptide 1
GLP1 neurons are in a prime position to rapidly modify ingestive behavior in direct response to transiently altered levels of metabolic cues (e.g., leptin, glucose) or to neural modulators from other brain sites, including POMC neurons in the arcuate nucleus.
From: Williams Textbook of Endocrinology
This drug works on the arcuate nucleus of the hypothalamus (ARC).
The ARC, located around the third ventricle near the median eminence, is involved in many processes including regulating the release of hormones (eg, GnRH and prolactin) from the anterior pituitary, the LH surge, lactation, appetite and growth hormone release.
What is the function of the arcuate nucleus of the hypothalamus?
The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient availability.