Assumptions are fine as long as they are convenient and work. But science has a tendency to treat them as sacred cows, forgetting that they are unproven assumptions, and then to suddenly forget they exist when they become inconvenient.
And modern science seems to have a serious problem admitting that there are any limits to what might be knowable through science. Their method, logically, cannot determine the truth of everything, but it’s rare to find a scientist who will admit that boundary exists. So they keep trying to bend science towards questions to which is it unsuited to answer, with predictably ridiculous results.
One area where science is particularly bad is studying stuff that is smart enough and sneaky enough not to want to be studied.
That is a comment that may not make sense to most folks around here—and I am not going to try to explain it further—bumps up against too many modern prejudices.
However—in my opinion that is a fatal flaw of science that eventually will have been shown to be its undoing.