>> There has been long term meta-analyses done on melatonin. It’s apparently safe with no rebound effect seen with other sleep medications. <<
Yes, because it’s actually what the body is SUPPOSED to use for this, but which modern environments prevent from being created in adequate quantities (blue light, phones, late-night stimulation, etc.)
I would note however, that a more-is-better approach from consumers leads most melatonin sellers to use incredibly unnaturally large doses.
It’s quite helpful for those with either mutations to enzymes responsible for melatonin syntheses or to proteins in the receptor. A chromosome microarray analysis can reveal mutations.
“...leads most melatonin sellers to use incredibly unnaturally large doses.”
If I take more than 1/4 of a tablet before bed it isn’t good. If I take even a half tablet I wake up with a headache and dizziness. Someone compared it to a hangover ... IDK.