I love my Strat (It’s an Eric Clapton Blackie - type. Love the maple fretboard), but these days I mostly play my PRS (and I’m NOT a lawyer or dentist!)...
I've got a Clapton "Brownie" --though it's not a Clapton sig, just an American reissue of a '54 Strat. I love it.
All of Clapton's early Strats were "Frankenstrats" meaning he'd take the neck off one guitar and swap it out with the body of a different one. He even put Strat necks on Teles.
If you or I did that, we'd kill the instrument's value but, then again, we're not Eric Clapton.