There was always a lot going on in Anatolia, but it had simmered down since the 8th century, when the Cimmerians and Scythians were rolling over everyone (at some point, including the Scythians rolling over the Cimmerians).
Persian rule began about 550 BC, which put an end to anyone else hammering the crap out of the residents. Persian rule was as good as foreign rule could be, and they used the local quislings and allowed local traditional practices in stuff like law, with an overlay of Persian law.
That went on a couple of centuries, ending when Alexander the Great led his Macedonians through the region, burning his ships after his army had crossed into Anatolia. After that, it was conquer or die. He actually did both. :^)
Appreciated. Bookmarking for later reference.