I hear you brother. I got rid of my Ruger Super Redhawk for being too heavy. I never carried it.
While .45 is my go to caliber for man sized game. Mainly because if I hit you with one, even if I hit armor, you aren't just going to stand there looking at me, I prefer the superior click to bang ratio achieved by a wheel gun (namely damn near 188%) when dealing With critters of the furred variety. So, after having seen what it did to a big boar hog and his unfortunate head, I carry a .357 magnum with hard cast hunting rounds.
I have a problem with my colt .45, I occasionally experience click without bang. This is quite distressing to my imagination which conjures images of my punctured vitals immediately resultant upon the occurrence of such a faux pas. So I have opted for the Springfield EXD .45 auto, sporting 7 rounds of 188% click to bang confidence booster.
Why do you carry a .45? Because they don't make a .46.
The very first time you had a “click-no-bang” with your 45 you should have done a walk-thru: cleanliness, spring tension, primer contact, firing pin length, breech lock-up, barrel link slop, etc.etc.etc. Not to be tolerated or otherwise put up with.