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I’m more interested in the statement about aging with NAD+

“Over the next 18 years, the team expanded knowledge of the relationship between NAD+ and CD38. They reported a link between the activation of CD38 and an increase in a type of cells that are shut down by the body but refuse to die. These cells are called senescent cells. The team also linked CD38 to the breakdown of an NAD+ precursors called nicotinamide mononucleotide and wonky mitochondria.

Both of those outcomes are due to CD38 involvement in a cellular signaling pathway, which plays a role in cell death, stress response, glucose management, among others.

In 2020, the team reported in Nature that CD38 is mainly found on immune cells, and NAD+ declined as the amount and percentage of CD38 enzymes increased in aged mice, compared to younger mice. The authors write that this supports the idea that aging is due to low but persistent levels of inflammation — not due to an infection — that researchers have termed inflammaging. It is the response of the innate immune system to the damage created by dysfunctional cells, and it is a central pillar of age-related diseases, according to the scientists.”