[Wuli]

"We now know that the evolution of soft-bodied cephalopods involved similarly massive genome changes, but the changes are not whole-genome duplications but rather immense genome rearrangements, as if the ancestral genomes were put in a blender," explains University of Chicago neurobiologist Clifton Ragsdale."

If trying to explain that on an evolutionary basis, it suggests the cephalopods genome advanced during a period, or periods where conditions on earth were changing on rapid time scale, more so than a slow process over longer time spanss.

[Aevery_Freeman]

Such rapid changes would seem unlikely in their more homeostatic environment - a truly remarkable family.