Funny thing...high-fructose corn syrup and other artificial sweeteners have their own issues regarding “satiety”/the “that’s enough” signal, compared to actual sugar.
Many believe we can lay a lot of blame on high-fructose corn syrup for a lot of diet related problems. One even said Japan managed quite well on a high carb diet until we introduced high fructose corn syrup to their culture. In fact he said when they started removing fat from food they tasted awful so they replace the fats with fructose. Could be, no expert but he makes a case..........