Let me explain why boosters can be a double edged sword when it comes to ADE.
2 main ways we know ADE is caused:
1.Ab titers are too low to neutralize virus, causing the situation you see in my comic
2.Ab only weakly bind the virus, acting as if there were low titers. pic.twitter.com/m1v1Cth5tP— AMM, MD (@AMcA32449832) August 19, 2021
They are scrambling to get boosters out bc Ab titers are dropping while there is still quite an active specific Tc population. But this strategy would require booster every time titers drop (which we see is <6 mo). Every injection increases adverse fx & chance for anaphylaxis.— AMM, MD (@AMcA32449832) August 19, 2021
But here is the kicker:
We already know from studies that vax-induced Abs bind the virus much weaker than Abs produced by natural immunity. If those Abs are weak enough to act like a sub-neutralizing titer, u can set up the same exact scenario for ADE. pic.twitter.com/JpxD6GHpN4— AMM, MD (@AMcA32449832) August 19, 2021
