"When the highest binding affinity of GO‐Spike‐ACE2 docking (−9.1 kcal mol−1) was examined in detail, GO showed strong affinity against amino acids of the spike‐RBD via 2 hydrophobic, 12 hydrogen, and 1 charge interaction with ASP427, a total of 15 bonds, and as well as 6 van der Waals forces which all explained the strong interaction with the ACE2 (Figure 3). On closer examination, (Table S2, Supporting Information) GO could act as a multiple H‐donor and H‐acceptor with strong H‐bonds ranging from 1.74 Å to 2.93 Å. Moreover, electrostatic‐pi–anion interaction of 427 ASP spike residue with GO is important for both increasing the binding strength and affecting the load density in the close chemical environment."
This GO efficacy, if true, would also directly interfere with the mRNA vaccines.
“This GO efficacy, if true, would also directly interfere with the mRNA vaccines.”
Did you find that conclusion in the paper? I didn’t see it. Could you point it out?