Otherwise, stay away from the big cities.
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That is my view as well. I don’t even like just passing through them on the freeway. One of the last times I was driving through Chicago on 294, I had a flat tyre. I was just barely out of my car surveying the situation when some guys pulled up and cleaned my wallet out.
That is so unfortunate.
If I had to go through a big city, if I were to travel in the states, I’d be doing reconnaissance, maps and google maps and maybe even a flyover (haha) beforehand.