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To: 2aProtectsTheRest
I'm not sure what you are getting at. It is established that SARS survivors are not only still immune to SARS 17 years later but they are also immune to Covid.

https://www.nature.com/articles/s41586-020-2550-z

In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein. Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARS-CoV infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2. We also detected SARS-CoV-2-specific T cells in individuals with no history of SARS, COVID-19 or contact with individuals who had SARS and/or COVID-19 (n = 37).

If it makes you feel better to continue to be terrified and continue the narrative that we all need mRNA shots and vaccine passports and the variants are going to be super dangerous to everyone and everything the CDC and WHO say are real....then be my guest. Keep being scared.

You seem like a smart guy. Take a second to go back through every government and health organization mandate over the past 15 months. EVERY single time they exaggerated, hid the truth, told half truths and erred on the side of tyranny. EVERY SINGLE TIME.

Two weeks ago Fauci said the vaccinated needed to continue wearing masks because of the "variants". Now today they say we don't need to.

What changed?

Public opinion is what changed. This is not about health. It is about grasping as much control as the government can get away with.

90 posted on 05/13/2021 2:30:55 PM PDT by nitzy
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To: nitzy
"I'm not sure what you are getting at. It is established that SARS survivors are not only still immune to SARS 17 years later but they are also immune to Covid."

No, it's established that SARS survivors have some quantity Memory T cell lymphocytes (and likely Memory B cell lymphocytes) from their sickness. That isn't surprising in the least. Aside from rare situations where Memory lymphocytes are wiped out (e.g. Measles infection, scarily enough), you have Memory T cell and Memory B cell lymphocytes from pretty much every infection you've ever suffered still present in your body. That's how the human immune system works. And it's still subject to antigenic drift and shift.

What your quote (and the linked article) is discussing is the presence of T cell lymphocytes specific to the nucleocapsid antigen ("N protein"). It also discussed cross-reaction between SARS and COVID-19 T cells, indicating that the N protein similarities are such that MHC binding remains possible. What it most certainly does NOT claim is that people who recovered from SARS are "immune" to SARS-CoV-2 infection. From the article:

"Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections1." and "Understanding how pre-existing N- and ORF1-specific T cells that are present in the general population affect the susceptibility to and pathogenesis of SARS-CoV-2 infection is important for the management of the current COVID-19 pandemic."

All of which is very true. The presence of cross-reactive Memory T cell lymphocytes indicates the potential for variance in clinical severity for the disease. It could indicate neutralizing immunity, or it could indicate reduction in risk of severe illness from COVID-19, or it could mean very little at all. As I said previously, if you wanted to test that, you'd need challenge trials. And given the already explored risk of antibody-dependent enhancement related to antibodies produced against the N protein, challenge trials carry serious risk of ADE-induced severe illness or death. Hence, conducting challenge trials is unethical and unlikely. Best we can do is survey the SARS 2003 and MERS 2012 survivors and see whether they show symptoms and/or severe illness at a different frequency than cohorts of similar risk profiles.

"If it makes you feel better to continue to be terrified"

I have repeatedly stated there is no reason for panic with COVID-19. This is a strawman argument.

"and continue the narrative that we all need mRNA shots"

I have never stated that everyone needs an mRNA shot, or really any COVID-19 vaccine. I have stated the fact that people who have not recovered from severe COVID-19 illness will very likely benefit from a safe and effective COVID-19 vaccine and have encouraged people to do their own research with authoritative sources to better understand why and be able to make an educated decision about what's best for their own individual health and wellbeing.

"and vaccine passports"

These aren't even a real thing at this point. It's a vaguely named concept with no details. I have no opinion on something that nobody knows anything about because it doesn't exist and hasn't even been proposed in detail. I've certainly never stated that everyone needs one.

"and the variants are going to be super dangerous to everyone and everything"

The dominant variants change the variables, but none thus far have turned COVID-19 into anything more than a slightly worse version of the original. There is always a risk of a mutation that creates a worse situation, but thus far the vaccines we have available are working against all known variants and with the third generation platform, we have the ability to produce updated versions in a matter of weeks. That's why I'm not concerned about either the current variants or future ones. We have the ability to stay ahead of them.

"Two weeks ago Fauci said the vaccinated needed to continue wearing masks because of the "variants". Now today they say we don't need to. What changed?"

Nothing changed: Fauci is still an idiotic media hound doing everything he can to get his stupid face on TV. I don't listen to Fauci. I hope you don't either. Follow the published scientific work. You linked to Nature, which is excellent. Nature is a great source for published research. Anyone who's been following the actual science (rather than what other people claimed about the science) shouldn't be scared.

91 posted on 05/13/2021 3:01:35 PM PDT by 2aProtectsTheRest (The media is banging the fear drum enough. Don't help them do it.)
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