Unfortunately, large scale trials are expensive. There were a couple HCQ trials, including the University of Minnesota HCQ trial that was funded by Novartis and others, but the trials showed no actual benefit. There are now a couple of ivermectin studies starting. Unfortunately, the internet hype never seems to translate to reality, as several Freeper MDs with hands on clinical COVID experience have stated. And it’s not just cheap generics that this applies to. Several super expensive drugs, like Remdesivir, have also been hyped, only to show disappointing results in the real world.
Yeah, that MN study of HCQ is an example of a study designed to fail. That study was looking at is as prophylaxis not as a treatment. They didn’t add zinc or vitamin D or C or antibiotics. They didn’t follow the protocols designed and used by for example the Dr. in upstate NY, the infectious disease clinic in Marseilles, and the virologist from Yale. It failed, and was supposed to fail. Easy to make a trial fail.
I don’t think it would work as prophylaxis. Not even the vaccines do that. The question is, will these combinations reduce severity of infection, reduce risk of hospitalization and death, keep viral load low etc. Could they be effective treatments for all the people who for whatever reason are not vaccinated and catch the virus. That’s the only question to study imo, and the protocols are well established and plenty of pilot studies done by these and other doctors.