No, I don’t think that’s been “proven” at all.
Smallpox, measles, influenza, malaria, cholera, typhoid and even corona and rhinovirus all took their toll.
Now I have read that SOME are proposing the plagues in early New Spain (Central Mexico today) were hemorrhagic fevers but that was a localized event only and did not spread north or south, and certainly NOT to the lands that would become the USA and Canada, or South America and the Caribbean.
Megadrought and Megadeath in 16th Century Mexico
"Recent epidemiologic research suggests that the events in 1545 and 1576, associated with a high death rate and referred to as cocoliztli (Nahuatl for "pest"), may have been due to indigenous hemorrhagic fevers"https://wwwnc.cdc.gov/eid/article/8/4/01-0175_article
Recent in this context was about 20 years ago when they isolated the pathogen.
These were the most densely inhabited parts of the New World outside Peru. Once you get to the future US, Canada and other areas populations weren't large.