There’s some evidence that anti-inflamatories such as dexamethasone, and budesonide and such, corticosteriods, can be helpful both when in early stages and in later stages when in ICU
I wonder what combining HCQ and Zinc, and some corticosteriod would do in early stages? Some early reports claimed corticosteriods taken internally would increase risk and complications, but other reports say it helps- according to the Doc you posted about a few days ago- He stated giving it early, in nebulizer, and not to wait till person was in serious trouble-
COVID-19 never killed anybody
by Ted Noel MD July 7, 2020 in Healthcare, Opinions
If all you get is the Wuhan Flu, you may get a bit sick, but you won’t even need to go to the hospital. You’ll get over it. That’s because you don’t get a “Cytokine Storm.”
In plain English, CS is a different disease process. It’s an uncontrolled release of signaling molecules that engage the immune system at ludicrous speed. A number of different infections can trigger it. An infection is needed before the Storm can start, but the Storm is a different process.
Once it’s underway, it drives the train. We know that the risk of dying from CS following COVID-19 in Florida if you are under age 25 is 0.02%, but if you are over 85, it’s 24.5% (FL Dept. of Health as of July 6).
That 1,225x difference in risk proves that something else is in play. The infection is necessary, but it’s not sufficient. CS requires something more than just infection such as COVID-19, SARS, or H5N1 flu.
In general, age and infirmity are correlated with bad outcomes, but we don’t know in any detail what factor within those categories is needed. What we do know is that the interventions that work don’t have all that much to do with antiviral effects.
Multiple studies have shown that hydroxychloroquine works to reduce severity and duration of the infection complex (COVID + CS) if given in the earlier stages of the disease. We also know that HCQ has both antiviral and immune modulating effects. Which of its effects is important with COVID-19 is not entirely clear.
But as we look further, studies have shown that dexamethasone, a common, inexpensive steroid, has beneficial effects, most likely by reducing CS. And new reports indicate that early administration of budesonide, an inhaled steroid that only gets to the lungs, can rapidly reverse the onset of CS.
The common feature of these treatments is an anti-inflammatory effect. HCQ is a mild anti-inflammatory, inhaled budesonide works the same way in the lung, and dexamethasone is a more potent systemic anti-inflammatory.
If we add suggestive data that non-steroidal anti-inflammatories may reduce inflammatory symptoms of respiratory virus infections, we start to see a strongly suggestive picture that CS is the major culprit.
When we look at drugs with antiviral effects, the picture isn’t so clear. A search of PubMed reveals no strong candidates for therapy. Lay news reports have remdesivir reducing hospital stays, but detailed studies are still in the pipeline.
In short, antivirals don’t seem to be all that useful in advanced COVID-19 cases. At the same time, viral load on admission does not seem to match outcome. - But viral load does match inflammatory markers in critically ill patients.
Putting the viral load data together doesn’t tell us much. That suggests that antiviral therapy isn’t likely to be terribly helpful in the critically ill patient. And that seems to be what we’re seeing. - The disease that kills people is CS, not COVID-19.
https://noqreport.com/2020/07/07/covid-19-never-killed-anybody/
RE: There’s some evidence that anti-inflamatories such as dexamethasone, and budesonide and such, corticosteriods, can be helpful both when in early stages and in later stages when in ICU
In his most recent interview. Dr. ZELENKO has also said that in later stages of CoVid-19, he is administering anti-inflammatories.
He continues to strongly advocate use of his HCQ+AZITHROMYCIN +ZINC cocktail in the early stages of the disease to prevent hospitalizations.