SYMPTOMS
Doctors rush to understand COVID-19’s second-week crash
...Doctors have now described alarming situations in which patients with COVID-19 suddenly and inexplicably become critically ill around the eighth day after being infected with the virus.
... Doctors, however, aren’t sure why the second week seems to be particularly dangerous for some with COVID-19.
“It’s one of those bizarre things because it doesn’t follow any trajectory of what we know in medicine,” said Dr. Sampson Davis, an emergency medicine physician at several New Jersey hospitals....
...While it’s clear there are numerous causes of the second-week crash, doctors still can’t predict which of their patients will crash. Age may play a role, but crashes are occurring in young patients as well. Patients with underlying medical conditions such as hypertension, diabetes and obesity seem to be at higher risk.
Nevertheless, doctors are taking action, instituting new precautions to prevent the second-week crash...
https://abcnews.go.com/Health/doctors-rush-understand-covid-19s-week-crash/story?id=70457111
and goodnite
MedCram Lecture
May 6
Dr. Roger Seheult
Coronavirus Pandemic Update 67: COVID-19 Blood Clots - Race, Blood Types, & Von Willebrand Factor
Dr. Seheult continues his review of journals and illustrates more of the possible pathway for blood clot (thrombosis) formation in COVID-19. See how oxidative stress of the endothelium (lining of the blood vessels), Von Willebrand factor, racial differences, and blood types may have a significant effect on COVID-19 severity and fatality rates.
https://www.youtube.com/watch?v=JOlVkES_kC8
Of Note: a paper was mentioned in the comments, with this summary: “...decreased ADAMTS13 contributes to coagulation. Here is some research showing that Vitamin D “up-regulated ADAMST13 expression” in an in-vitro study. “
I think it’s been posted to the thread some time back but just in case a refresher
https://pubmed.ncbi.nlm.nih.gov/28853522/