[exDemMom]

None of the material I could find written about the isolation of the 1918 influenza virus indicates whether it was first or second wave virus. I highly suspect that it was a second wave virus, given the lethality the virus caused in subsequent mouse and chick embryo experiments after the virus was recreated.

There was quite a bit of controversy over publishing its sequence. Influenza research can be a very sensitive topic, since many researchers (and policy makers) believed that the next pandemic would be another influenza virus. The 1917-1919 H1N1 was particularly lethal (but not as much as Covid-19). We still have circulating H1N1—the 2009 pandemic was distantly related to the 1917-1919 pandemic virus—but it is much attenuated from that time.

[Covenantor]

Thank you

[Tolerance Sucks Rocks]

The 1917-1919 H1N1 was particularly lethal (but not as much as Covid-19).

You sure. I read that the fatality rate for Spanish Flu was 10%. The current CFR for USA for COVID-19, using official number, is around 3 to 4 percent. (Resolved CFR could be somewhat higher when its all over -- it's high as a kite now.)

[BDParrish]

"The 1917-1919 H1N1 was particularly lethal (but not as much as Covid-19)."Dr. Terrence Tumpey at CDC is one of my famous hero flu-fighters. In his work, he was the only one allowed to touch the virus, he found that only when all the 8 viral rna's were there did they get the explosive replication. What was scary was that in working the H5N1 Avian flu they got that same explosive replication with one particular mutation. It is in a part of the sequence where mutations are rare, but the possibility must be anticipated.

Thank you so much for your kind intruction and expertise here on our wonderful forum. I do not thank you enough sorry and please correct me I do treasure your correction.