Med Drug Discov. 2020 Mar;5:100028.
doi: 10.1016/j.medidd.2020.100028. Epub 2020 Mar 26.
Can Early and High Intravenous Dose of Vitamin C Prevent and Treat Coronavirus Disease 2019 (COVID-19)?
1 High-dose intravenous VC has also been successfully used in the treatment of 50 moderate to severe COVID-19 patients in China. The doses used varied between 10 g and 20 g per day, given over a period of 8–10 h. Additional VC bolus may be required among patients in critical conditions. The oxygenation index was improving in real time and all the patients eventually cured and were discharged [18]. In fact, high-dose VC has been clinically used for several decades and a recent NIH expert panel document states clearly that this regimen (1.5 g/kg body weight) is safe and without major adverse events [19].
https://doi.org/10.1016/j.medidd.2020.100028
China reportedly lobbied the EU to dial down criticism of its Covid-19 disinformation campaigns
EU officials appear to have delayed and rewritten part of a report that worried Chinese diplomats.
By Zeeshan Aleem Apr 25, 2020, 6:30pm EDT
China has reportedly successfully lobbied European Union officials to rewrite and soften language in a new report criticizing Beijing for spreading disinformation around coronavirus.
According to reports in the New York Times and Politico, Chinese diplomats managed to persuade EU officials to scrap a reference to China running a “global disinformation” campaign, and also remove reference to Beijing’s criticism of the French response to the pandemic.
The final version of the report reads mildly: “Official and state-backed sources from various governments, including Russia and — to a lesser extent — China, have continued to widely target conspiracy narratives and disinformation.”
The lobbying campaign represents the latest instance of the Chinese government attempting to control narratives in order to defend its reputation, after failing to keep coronavirus within its borders and to properly alert other countries of the threat the new virus poses.
Recently, Chinese officials and news outlets have deliberately spread false information — most notably the conspiracy theory that the US Army introduced the novel coronavirus to Wuhan and started the pandemic itself.
NOT PEER REVIEWED
A transcriptional regulatory atlas of coronavirus infection of
human cells
Scott A Ochsner & Neil J McKenna
” Here, as a service to the research community to catalyze the development of novel CoV therapeutics, we generated consensomes for infection of human cells by MERS, SARS1 and SARS2 CoVs. We then analyzed the extent to which high confidence transcriptional targets for these viruses intersected with genes with elevated rankings in transcriptomic and ChIP-Seq consensomes for cellular signaling pathway nodes....
https://www.biorxiv.org/content/10.1101/2020.04.24.059527v1.full.pdf
in particular: line 255-263: ???
” To investigate the specific nature of the crosstalk implied by this overlap in the context of the airway epithelium, we first identified a set of 16 genes that were in both the ALL CoV and PGR TC95s. We then retrieved two SPP experiments involving treatment of A549 airway epithelial cells with the PGR full antagonist RU486 (RU), alone or in combination with the GR agonist dexamethasone (DEX). As shown in Figure 6 , there was nearly unanimous correlation in the direction of regulation of all 16 genes in response to CoV infection and PGR loss of function.
line 262-263-——> These data indicate that antagonism between PGR and IFNR signaling in the airway epithelium may predispose pregnant women to infection by SARS2.”
Drink more orange juice!