I see that they gave 450mg doses to a group of patients and 2 of them died from complications. Why start with such a high dose? My wife has been taking this stuff for Lupus for the past 35 years. She takes 250mg.
As I understand it...the ‘maintenance dose’ for those with Lupus or Rheumatoid Arthritis is fairly low....while someone with malaria might take a higher dose. [OTOH -those going into an area with malaria might take the lower dose as a prophylactic...to keep from getting malaria while in an malaria prone area.]
The dose scheme I recall for the COVID 19 was 200 mg x 3 times for the first day - then 200 mg x 2 for days 2 thru 6...and the Zn and ZPack also taken.
The higher dose was never shown to be a problem for malaria.
IMPORTANT NOTE - this treatment is REALLY effective if given ‘earlier’ - and one doctor in NY had 900 patients who used it...and less than 10 required hospitalization. Obviously if the treatment is not started until the person is in serious condition, it might be less effective. AND - patients who get placed on a ventilator are already seriously compromised...because the COVID-19 virus tends to shut down the immune system and it can cause organ damage. A treatment too late - is just that.
The NY doctor with 900 patients - had one die...and according to the reports, the patient did not follow the prescribed regimen.