This should be a post by “Q” -
Virol J. ***** 2005 Aug 22;2:69. *****
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.
Vincent MJ1, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST.
Author information
1
***** Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. mvincent@cdc.gov *****
Abstract
BACKGROUND:
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
RESULTS:
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
CONCLUSION:
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
PMID:
16115318
PMCID:
PMC1232869
DOI:
10.1186/1743-422X-2-69
The new, confirmed COVID-19 cases in the U.S. today was LESS THAN YESTERDAY.
I have been watching these stats very carefully for the past week. BEEN WAITING for this reduction in new cases.
QUESTION: WHY IS THIS SIGNIFICANT?
ANSWER: Because for exponential growth to continue, the number of new cases every day has to be larger than the previous day(s).
THIS IS THE "BELL CURVE" they sometimes talk about.
Last few days the total NEW U.S. CASES were:
5911 6251 6816 8478 11107 8816
That 8,816 today is a strong indication THE 2020 COVID-19 growth curve in the U.S. is STARTING to Flatten.
This means the panic can start to come to an end, and THIS IS PROBABLY WHY PRESIDENT TRUMP IS PLANNING TO REOPEN THE COUNTRY BEFORE EASTER.
don’t you get tired of doing the Feds job?
so, how does this get to Fouci & Hahn ? and how to ask the CDC to look for more stuff.
Thanks; a very thorough presentation - as PubMed usually is. :)