Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
Clinical sensitivity of RT-PCR on swabs taken on days 1-5 of symptoms was 100%, with no differences comparing swab and sputum samples taken simultaneously. ...Shedding of viral RNA from sputum oulasted the end of symptoms
https://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1.
NOTE COMMENT:
Christian Drosten:
Our comprehensive shedding study on the Munich #COVID2019 cluster: proof of replication in upper resp tract, virus in stool but no live virus isolation fom stool, long shedding but no live iso after 1 week in sputum.
https://twitter.com/c_drosten/status/1236967026150854657
note also:
Trevor Bedford
@trvrb
23h
Replying to
@trvrb
Thanks to rapid work by
@UWVirology
and
@seattleflustudy
we now have 13 #HCoV19 genomes from Washington State. All 12 of the genomes from community cases have grouped into an emerging outbreak clade.
This figure shows the genetic relationships among these viruses, where all the WA viruses are closely related. Given this shared ancestry pattern, it looks like the large majority of current cases in WA derive from a single introduction event.
Charles Chiu
@cychiu98
Mar 6
Hi all, we submitted the #COVID-19 genome sequence from the viral strain linked to the #GrandPrincess cruise ship off coast of San Francisco to #GISAID. Phylogenetic analysis shows that it clusters with the outbreak clade circulating in Washington State. @UCSF #coronavirus
https://twitter.com/trvrb/status/1236799358718185472