Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
https://www.thelancet.com/pb-assets/Lancet/pdfs/S014067362305663.pdf
Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital.
91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients).
Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p<0·0001), and d-dimer greater than 1 µg/L (18·42, 2·64–128·55; p=0·0033) on admission.
Median duration of viral shedding was 20·0 days (IQR 17·0–24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days.
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9,000 cases of coronavirus in the US could stem from Wuhan alone
Travel before the city’s lockdown could have led to thousands of U.S. infections.
The study, which is not yet peer reviewed, was posted on Sunday (March 8) on the preprint database MedRxiv. It should not be taken as a final word on how many coronavirus cases actually exist in the United States, because it focuses only on travel from Wuhan and does not include potential transmission from Italy, Iran, South Korea or other places where the new virus SARS-CoV-2 is widespread.
https://www.livescience.com/thousands-coronavirus-cases-in-us.html
Estimating the scale of COVID-19 Epidemic in the United States: Simulations Based on Air Traffic directly from Wuhan, China
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
https://www.medrxiv.org/content/10.1101/2020.03.06.20031880v1.article-info