“However there has been no widespread reported transmission to the endemic American population even where Asiatics are concentrated such as Flushing and Manhattan, New York, LA , San Francisco and college complexes.”
This suggests that the genetic factor is less significant than the environmental, or that they actually got people out ahead of the general outbreak.
Or the S has not yet HTF.
Tobacco-use disparity in gene expression of ACE2, the receptor of 2019-nCov
In current severe global emergency situation of 2019-nCov outbreak, it is imperative to identify vulnerable and susceptible groups for effective protection and care. Recently, studies found that 2019-nCov and SARS-nCov share the same receptor, ACE2. In this study, we analyzed four large-scale datasets of normal lung tissue to investigate the disparities related to race, age, gender and smoking status in ACE2 gene expression. No significant disparities in ACE2 gene expression were found between racial groups (Asian vs Caucasian), age groups (>60 vs <60) or gender groups (male vs female). However, we observed significantly higher ACE2 gene expression in smoker samples compared to non-smoker samples. This indicates the smokers may be more susceptible to 2019-nCov and thus smoking history should be considered in identifying susceptible population and standardizing treatment regimen.
https://www.medrxiv.org/content/10.1101/2020.02.05.20020107v2