The Corona virus hits men and asians harder:
Of note, the 2 male donors have a higher ACE2-expressing cell ratio than all other 6 female donors (1.66% vs. 0.41% of all cells, P value=0.07, Mann Whitney Test). In addition, the distribution of ACE2 is also more widespread in male donors than females: at least 5 different types of cells in male lung express this receptor, while only 2~4 types of cells in female lung express the receptor. This result is highly consistent with the epidemic investigation showing that most of the confirmed 2019-nCov infected patients were men (30 vs. 11, by Jan 2, 2020).
We also noticed that the only Asian donor (male) has a much higher ACE2-expressing cell ratio than white and African American donors (2.50% vs. 0.47% of all cells). This might explain the observation that the new Coronavirus pandemic and previous SARS-Cov pandemic are concentrated in the Asian area.
More at: https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1.full
>>Corona virus
Appreciate the work you’re both doing on collecting this information. Very interesting.
ACE2 gene maps to chromosome Xp22 -— X-linked?
https://www.ncbi.nlm.nih.gov/pubmed/23013041
“In the present study, significant association was remarkably found among Asians but not among Caucasians or African–Americans, suggesting possible ethnic differences in genetic backgrounds and the living environment.” -— Asian predisposition, based on ACE2 distribution in population?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747497/
Seems like the makings of a great targeted bioweapon.