A while back, when Quebec was having a referendum on independence, I think I remember hearing the Maritime Provinces (New Brunswick, Nova Scotia, Newfoundland and Labrador, and Prince Edward Island) were considering asking to join as American states if Quebec went independent.
The Maritime economies are generally so dependent on transfer payments, the US might not want the expense. And since they are Quebec’s natural market, Quebec would want to keep them.
And I expect they’d pull each other into penury.