I think a saw an interview with Jim Lovell about an extended Gemini mission, with rendezvous.
Towards the end, can’t remember if it was Lovell, but one had go #2. It was a messy production back then, especially in an even smaller vehicle, so the bathroom humor was “We only have 36 hours more. Can’t you hold it?”
“...you were supposed to go before we left!!”
Apparently it was a time consuming process.