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PAR is a cellular expressed protein, enzyme and as with all such molecular structures, it has an active ‘pocket’ with unique dipole arrangements..

Drugs are small molecules that have polarity designed to hit certain active pockets, like key to lock.

Taking out a larger PAR molecile with a small molecule in this case disables PAR from doing its things with calcium molecules.

The antibiotic that is a possible solution is already approved so it can save ten years to market. But the approved dosage of the particular antibiotic falls short, so an increased dosage needs to be studied.

But what some of the excellent FR contributors are pointing out is that an increased circulation of antibiotics in the human population has a significant downside.

Now that we know precisely that PAR is the cause, a thorough study by nutritional chemists that can link precisely which dietary elements and regimes such as called out in the excellent comments of this thread including things like ketosis, must link all to precise measurements of effects on PAR. So now they have a target to test against.

This is a problem affecting hundreds of millions. We should expect Johns Hopkins or any of the network of NIH to get the funding to hop on this pronto.